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Comment on 'Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets' by Lam et al.

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Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalTwin Research and Human Genetics
Issue number2
Early online date19 Mar 2018
Publication statusPublished - 1 Apr 2018


Intelligence and educational attainment are strongly genetically correlated. This relationship can be exploited by Multi-Trait Analysis of GWAS (MTAG) to add power to Genome-wide Association Studies (GWAS) of intelligence. MTAG allows the user to meta-analyze GWASs of different phenotypes, based on their genetic correlations, to identify association's specific to the trait of choice. An MTAG analysis using GWAS data sets on intelligence and education was conducted by Lam et al. (2017). Lam et al. (2017) reported 70 loci that they described as 'trait specific' to intelligence. This article examines whether the analysis conducted by Lam et al. (2017) has resulted in genetic information about a phenotype that is more similar to education than intelligence.

    Research areas

  • calcium channel, cerebellum, gene expression, general cognitive ability, GWAS, neurodevelopment, nootropics, potassium channel, synapse

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