Edinburgh Research Explorer

Comparative biology and expression of TENP, an egg protein related to the bacterial permeability-increasing family of proteins

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)99-108
JournalGene
Volume538
Issue number1
Early online date10 Jan 2014
DOIs
Publication statusPublished - 10 Jan 2014

Abstract

The 'transiently expressed in neural precursors' (TENP) gene product is a member of the bacterial/permeability-increasing (BPI) family of antimicrobial proteins but was first identified as having a role in an early neurological event occurring in post-mitotic cells. However, recent characterisation of the egg white proteome has shown that TENP is an important egg component constituting ~0.1-0.5% of the total protein and suggesting it is expressed in the adult oviduct. In this study we confirmed quantitatively that the expression of TENP is largely confined to the tubular glands of the magnum of the oviduct, where egg white synthesis occurs, with around 10,000 times more expression than in the embryo where TENP was first identified. TENP expression is significantly increased with the administration of oestrogen or progesterone (P

ID: 12564797