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Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms

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http://pubs.rsc.org/en/Content/ArticleLanding/2014/MB/C4MB00354C#!divAbstract
Original languageEnglish
Pages (from-to)2935-2941
JournalMolecular BioSystems
Volume10
Issue number11
Early online date11 Aug 2014
DOIs
Publication statusPublished - 18 Aug 2014

Abstract

Transcription factors play a key role in the development of a disease. ChIP-sequencing has become a preferred technique to investigate genome-wide binding patterns of transcription factors in vivo. Although this technology has led to many important discoveries, the rapidly increasing number of publicly available ChIP-sequencing datasets still remains a largely unexplored resource. Using a compendium of 144 publicly available murine ChIP-sequencing datasets in blood, we show that systematic bioinformatic analysis can unravel diverse aspects of transcription regulation; from genome-wide binding preferences, finding regulatory partners and assembling regulatory complexes, to identifying novel functions of transcription factors and investigating transcription dynamics during development.

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