Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

Helen M. Marriott; Paul G. Hellewell; Moira K. B. Whyte; David Dockrell

doi:10.1016/j.vaccine.2006.09.024

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

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Helen M. Marriott
Paul G. Hellewell
Moira K. B. Whyte
David Dockrell

Related Edinburgh Organisations

Original language	English
Pages (from-to)	2485-2490
Number of pages	6
Journal	Vaccine
Volume	25
Issue number	13
DOIs	https://doi.org/10.1016/j.vaccine.2006.09.024
Publication status	Published - 22 Mar 2007
Event	5th International Symposium on Pneumococci and Pneumococcal Diseases - Alice Springs, Australia Duration: 2 Apr 2006 → 6 Apr 2006

Abstract

The pulmonary innate response to low-dose bacterial challenge requires functioning alveolar macrophages (AM) but also subsequent macrophage apoptosis. To address the role of reactive oxygen species (ROS) and nitric oxide (NO) in AM apoptosis, sub-clinical Streptococcus pneumoniae infection was established in gp91(phox-/-) and inducible NO synthase deficient (iNOS(-/-)) mice. Both AM apoptosis and the number of macrophages containing apoptotic bodies are reduced in iNOS(-/-) as compared to control or gp91phox(-/-) mice. iNOS(-/-) mice recruit neutrophils and generate TNF-alpha to compensate for impaired AM competence but ROS deficiency has no apparent effect on AM function in this model. (C) 2006 Elsevier Ltd. All rights reserved.

Research areas

macrophages, apoptosis, pneumococci, mice, nitric oxide, ALVEOLAR MACROPHAGES, INDUCED APOPTOSIS, OXIDATIVE STRESS, PHAGOCYTOSIS, CONTRIBUTES, COMMITMENT, ACTIVATION, MECHANISMS, RESISTANCE, CLEARANCE

Event

5th International Symposium on Pneumococci and Pneumococcal Diseases

2/04/06 → 6/04/06

Australia

Event: Conference

ID: 17166475