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Control structure and limitations of biochemical networks

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Original languageEnglish
Title of host publicationProceedings of the 2010 American Control Conference
Pages6668-6673
Number of pages6
DOIs
Publication statusPublished - 1 Jun 2010
Event2010 American Control Conference - Baltimore, United States
Duration: 30 Jun 20102 Jul 2010
http://acc2010.a2c2.org/

Conference

Conference2010 American Control Conference
Abbreviated titleACC 2010
CountryUnited States
CityBaltimore
Period30/06/102/07/10
Internet address

Abstract

Biochemical networks typically exhibit intricate topologies that hinder their analysis with control-theoretic tools. In this work we present a systematic methodology for the identification of the control structure of a reaction network. The method is based on a bandwidth reduction technique applied to the incidence matrix of the network's graph. In addition, in the case of mass-action and stable networks we show that it is possible to identify linear algebraic dependencies between the time-domain integrals of some species' concentrations. We consider the extrinsic apoptosis pathway and an activation-inhibition mechanism to illustrate the application of our results.

    Research areas

  • biocontrol, linear algebra, time-domain analysis, control structure, biochemical networks, bandwidth reduction technique, incidence matrix, linear algebraic, time-domain integrals, extrinsic apoptosis pathway, activation-inhibition mechanism, Network topology, Biochemical analysis, Control systems, Bandwidth, Time domain analysis, Biological control systems, Computer networks, Control system analysis, Systems biology, Plants (biology)

Event

2010 American Control Conference

30/06/102/07/10

Baltimore, United States

Event: Conference

ID: 81296223