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Control structure and limitations of biochemical networks

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Original languageEnglish
Title of host publicationProceedings of the 2010 American Control Conference
Number of pages6
Publication statusPublished - 1 Jun 2010
Event2010 American Control Conference - Baltimore, United States
Duration: 30 Jun 20102 Jul 2010


Conference2010 American Control Conference
Abbreviated titleACC 2010
CountryUnited States
Internet address


Biochemical networks typically exhibit intricate topologies that hinder their analysis with control-theoretic tools. In this work we present a systematic methodology for the identification of the control structure of a reaction network. The method is based on a bandwidth reduction technique applied to the incidence matrix of the network's graph. In addition, in the case of mass-action and stable networks we show that it is possible to identify linear algebraic dependencies between the time-domain integrals of some species' concentrations. We consider the extrinsic apoptosis pathway and an activation-inhibition mechanism to illustrate the application of our results.

    Research areas

  • biocontrol, linear algebra, time-domain analysis, control structure, biochemical networks, bandwidth reduction technique, incidence matrix, linear algebraic, time-domain integrals, extrinsic apoptosis pathway, activation-inhibition mechanism, Network topology, Biochemical analysis, Control systems, Bandwidth, Time domain analysis, Biological control systems, Computer networks, Control system analysis, Systems biology, Plants (biology)


2010 American Control Conference


Baltimore, United States

Event: Conference

ID: 81296223