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Core alpha 1 -> 3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep

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  • Irma van Die
  • [No Value] Gomord
  • FNJ Kooyman
  • TK van den Berg
  • RD Cummings
  • L Vervelde

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    Rights statement: Copyright 1999 Federation of European Biochemical Societies.

    Final published version, 189 KB, PDF document

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalFEBS Letters
Volume463
Issue number1-2
Publication statusPublished - 10 Dec 1999

Abstract

Synthesis of parasite specific IgE plays a critical role in the defence against helminth infections. We report here that IgE from serum from Schistosoma mansoni infected mice and Haemonchus contortus infected sheep recognizes complex-type N-glycans from Arabidopsis thaliana, which contain R-GlcNAc beta 1-->4(Fuc alpha 1 -->3)GlcNAc beta 1-Asn (core alpha 1-->3-Fuc) and Xyl beta 1-2Man beta 1 --> 4GlcNAc beta 1-R (core beta 1 --> 2-Xyl) modifications, and honeybee phospholipase A2, which carries N-glycans that contain the core alpha 1-->3-Fuc epitope, Evidence is presented that core alpha 1-->3-fucosylated N-glycans bind a substantial part of the parasite specific IgE in serum of H, contortus infected sheep. These results suggest that the core alpha 1-->3-Fuc antigen may contribute to induction of a Th2 response leading to the production of IgE, In addition we show here that IV-glycans carrying core alpha 1-->3-Fuc and beta 1-->2-Xyl antigens are synthesized by many parasitic helminths and also by the free living nematode Caenorhabditis elegans. Since N-glycans containing the core alpha 1-->3-Fuc have also been implicated in honeybee and plant induced allergies, this conserved glycan might represent an important common IgE epitope, (C) 1999 Federation of European Biochemical Societies.

    Research areas

  • Hemonchus contortus, xylose, IgE, schistosome, RESPONSES, PHOSPHOLIPASE-A2, fucose, BEE VENOM, CARBOHYDRATE CHAINS, PROTECTIVE IMMUNITY, SCHISTOSOMA-MANSONI, PLANT, ANTIBODIES, LINKED OLIGOSACCHARIDES, GLYCOPROTEINS, glycoprotein allergen

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