Edinburgh Research Explorer

C-reactive protein, APOE genotype and longitudinal cognitive change in an older population

Research output: Contribution to journalArticlepeer-review

  • Thomas A S Lima
  • Amanda L Adler
  • Thais Minett
  • Fiona E Matthews
  • Carol Brayne
  • Riccardo E Marioni
  • on behalf of the Medical Research Council Cognitive Function and Ageing Study

Related Edinburgh Organisations

Original languageEnglish
JournalAge and Ageing
Issue number2
Early online date3 Dec 2013
Publication statusPublished - Mar 2014


circulating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cross-sectional evidence suggests that elevated CRP may even be protective in this age group. This study examines these associations longitudinally.

ID: 13393870