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Crystallization of globular proteins

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Original languageEnglish
Pages (from-to)3762-3764
Number of pages3
JournalPhysical Review E - Statistical, Nonlinear and Soft Matter Physics
Issue number3
Publication statusPublished - Mar 1997


Globular proteins can be crystallized by the addition of electrolyte or nonadsorbing polymer. Too much additive, however, gives rise to amorphous precipitates. By comparing existing data on various proteins with previous work on a model colloid-polymer mixture, we suggest an explanation for noncrystallization in terms of a hidden gas-liquid binodal inside the equilibrium fluid-crystal region of the phase diagram.

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