Edinburgh Research Explorer

CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes

Research output: Contribution to journalArticle

  • Elisabeth A P M Romme
  • John T Murchison
  • Lisa D Edwards
  • Edwin van Beek
  • David M Murchison
  • Erica P A Rutten
  • Frank W J M Smeenk
  • Michelle C Williams
  • Emiel F M Wouters
  • William MacNee
  • Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1369-77
Number of pages9
JournalJournal of Bone and Mineral Research
Issue number6
Publication statusPublished - Jun 2013


Osteoporosis is highly prevalent in chronic obstructive pulmonary disease (COPD) patients and has been related to several clinical features. However, most studies have been in relatively small COPD cohorts. Therefore, the objectives of this study were to compare bone attenuation measured on low-dose chest computed tomography (CT) between COPD subjects and smoker and nonsmoker controls, and to relate bone attenuation to clinical parameters, inflammatory biomarkers, and outcomes in a large, well-characterized COPD cohort. We studied 1634 COPD subjects, 259 smoker controls, and 186 nonsmoker controls who participated in a large longitudinal study (ECLIPSE). We measured bone attenuation, extent of emphysema, and coronary artery calcification (Agatston score) on baseline CT scans, and clinical parameters, inflammatory biomarkers, and outcomes. Bone attenuation was lower in COPD subjects compared with smoker and nonsmoker controls (164.9 ± 49.5 Hounsfield units [HU] versus 183.8 ± 46.1 HU versus 212.1 ± 54.4 HU, p 

    Research areas

  • Adult, Age Factors, Aged, Bone and Bones, Cohort Studies, Coronary Artery Disease, Coronary Vessels, Female, Humans, Male, Middle Aged, Osteoporosis, Pulmonary Disease, Chronic Obstructive, Sex Factors, Smoking, Tomography, X-Ray Computed, Vascular Calcification

ID: 15019490