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Cutting Edge: IL-6-Dependent Autoimmune Disease: Dendritic Cells as a Sufficient, but Transient, Source

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    Rights statement: Published in final edited form as: J Immunol. Feb 1, 2013; 190(3): 881–885. Published online Dec 24, 2012. doi: 10.4049/jimmunol.1202925

    Accepted author manuscript, 1 MB, PDF document

http://www.jimmunol.org/content/190/3/881
Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalJournal of Immunology
Volume190
Issue number3
DOIs
Publication statusPublished - 1 Feb 2013

Abstract

Mice lacking IL-6 are resistant to autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE), which is driven by CNS-reactive CD4(+) T cells. There are multiple cellular sources of IL-6, but the critical source in EAE has been uncertain. Using cell-specific IL-6 deficiency in models of EAE induced by active immunization, passive transfer, T cell transfer, and dendritic cell transfer, we show that neither the pathogenic T cells nor CNS-resident cells are required to produce IL-6. Instead, the requirement for IL-6 was restricted to the early stages of T cell activation and was entirely controlled by dendritic cell-derived IL-6. This reflected the loss of IL-6R expression by T cells over time. These data explain why blockade of IL-6R only achieves protection against EAE if used at the time of T cell priming. The implications for therapeutic manipulation of IL-6 signaling in human T cell-driven autoimmune conditions are considered.

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