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Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA-peptide conjugates

Research output: Contribution to journalArticle

  • L Bialy
  • J J Diaz-Mochon
  • E Specker
  • L Keinicke
  • M Bradley

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)8295-8305
Number of pages11
JournalTetrahedron
Volume61
Issue number34
DOIs
Publication statusPublished - 22 Aug 2005

Abstract

Peptide nucleic acids have become, arguably, one of the most interesting of DNA mimics. Herein the efficient solution phase synthesis of four novel 1-(4,4-dimethyl-2,6-dioxacyclohexylidene)ethyl/4-methoxytrityl (Dde/Mmt) protected PNA monomers is reported which were then used to synthesise PNA-peptide conjugates through a mild Dde deprotection strategy, which was fully orthogonal to Fmoc chemistry, allowing at will Fmoc peptide and Dde-PNA synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

    Research areas

  • PNA, Dde, Fmoc, orthogonality, conjugate, peptide, SOLID-PHASE SYNTHESIS, NUCLEIC-ACID, POLYAMIDE, THYMINE, DNA

ID: 1514167