Edinburgh Research Explorer

De novo formation and epigenetic maintenance of centromere chromatin

Research output: Contribution to journalReview article

Related Edinburgh Organisations

Open Access permissions



Original languageEnglish
Pages (from-to)15-25
Number of pages11
JournalCurrent opinion in cell biology
Early online date15 Jan 2019
Publication statusPublished - 1 Jun 2019


Accurate chromosome segregation is essential for cell proliferation. The centromere is a specialized chromosomal locus, on which the kinetochore structure is formed. The centromere/kinetochore is required for the equal separation of sister chromatids to daughter cells. Here, we review recent findings on centromere-specific chromatin, including its constitutive protein components, its de novo formation and maintenance mechanisms, and our progress in analyses with synthetic human artificial chromosomes (HACs).

Download statistics

No data available

ID: 80825436