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Debridement for periprosthetic joint infections: future therapies

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Original languageEnglish
JournalBone & Joint Research
Early online date24 Jun 2020
Publication statusE-pub ahead of print - 24 Jun 2020


Debridement is a central tenet in the management of prosthetic joint infections (PJIs). Modern debridement has three distinct stages: 1) surgical; 2) mechanical/physical; and 3) chemical.1 Given more recent understanding in the pathogenesis of PJI, the microscopic targeting of the bacterial biofilm and intracellular pathogens should also be included in the art of debridement. The adequacy of debridement is critical to the success of single-stage procedures, which have been shown to result in lower patient morbidity and healthcare costs. There is currently an unmet clinical need to optimize debridement in the management of PJI.

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