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Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

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Original languageEnglish
Article numbere1968
Number of pages11
JournalPLoS Neglected Tropical Diseases
Volume6
Issue number12
DOIs
Publication statusPublished - 2012

Abstract

Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a vaccine against filariasis may depend on its capacity to counter parasite-driven immunomodulation.

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