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DISC1 genetics, biology and psychiatric illness

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    Rights statement: Published in final edited form as: Front Biol (Beijing). Feb 1, 2013; 8(1): 1–31. doi: 10.1007/s11515-012-1254-7

    Accepted author manuscript, 799 KB, PDF document

Original languageEnglish
Pages (from-to)1-31
JournalFrontiers in Biology
Issue number1
Publication statusPublished - 1 Feb 2013


Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.
Keywords: DISC1, schizophrenia, depression, genetics, neural pathways

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