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Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)2838-2843
Number of pages6
JournalBioorganic & Medicinal Chemistry Letters
Volume17
Issue number10
DOIs
Publication statusPublished - 15 May 2007

Abstract

A series of adamantyl amide 11beta-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11beta-HSD1 over 11beta-HSD2 and possess excellent cellular potency in human and murine 11beta-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.

    Research areas

  • Metabolic syndrome , 11β-HSD1 , 11β-HSD2 , Inhibitor , Adamantane , Amide , Diabetes , 11β-Hydroxysteroid dehydrogenase , Enzyme inhibition , Hsd1

ID: 2148117