Original language | English |
---|
Journal | Molecular Psychiatry |
---|
DOIs | |
---|
Publication status | Published - 7 Jun 2018 |
---|
Psychiatric disorders are a group of genetically related diseases with highly polygenic architectures. Genome-wide association
analyses have made substantial progress towards understanding the genetic architecture of these disorders. More recently,
exome- and whole-genome sequencing of cases and families have identified rare, high penetrant variants that provide direct
functional insight. There remains, however, a gap in the heritability explained by these complementary approaches. To
understand how multiple genetic variants combine to modify both severity and penetrance of a highly penetrant variant, we
sequenced 48 whole genomes from a family with a high loading of psychiatric disorder linked to a balanced chromosomal
translocation. The (1;11)(q42;q14.3) translocation directly disrupts three genes: DISC1, DISC2, DISC1FP and has been linked to multiple brain imaging and neurocognitive outcomes in the family. Using DNA sequence-level linkage analysis, functional annotation and population-based association, we identified common and rare variants in GRM5 (minor allele frequency (MAF) > 0.05), PDE4D (MAF > 0.2) and CNTN5 (MAF < 0.01) that may help explain the individual differences in phenotypic expression in the family. We suggest that whole-genome sequencing in large families will improve the understanding of the combined effects of the rare and common sequence variation underlying psychiatric phenotypes.
ID: 57983698