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Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis

Research output: Contribution to journalArticle

  • A J Lucking
  • A Visvanathan
  • H Philippou
  • S Fraser
  • P J Grant
  • T M Connolly
  • S J Gardell
  • G Z Feuerstein
  • K A A Fox
  • N A Booth
  • D E Newby

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1333-9
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Issue number6
Publication statusPublished - 2010


The principal inhibitor of fibrinolysis in vivo is plasminogen activator inhibitor-1 (PAI-1). PAI-749 is a small molecule inhibitor of PAI-1 with proven antithrombotic efficacy in several preclinical models.

ID: 2499394