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Electrodrugs: an electrochemical prodrug activation strategy

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Original languageEnglish
JournalChemical Communications
Early online date24 Jul 2018
DOIs
Publication statusE-pub ahead of print - 24 Jul 2018

Abstract

The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(iv) prodrugs into their active Pt(ii) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.

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