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eMouseAtlas, EMAGE, and the spatial dimension of the transcriptome

Research output: Contribution to journalArticle

  • Chris Armit
  • Shanmugasundaram Venkataraman
  • Lorna Richardson
  • Peter Stevenson
  • Julie Moss
  • Liz Graham
  • Allyson Ross
  • Yiya Yang
  • Nicholas Burton
  • Jianguo Rao
  • Bill Hill
  • Dominic Rannie
  • Mike Wicks
  • Duncan Davidson
  • Richard Baldock

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    Rights statement: © The Author(s) 2012. Open access document

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http://link.springer.com/article/10.1007%2Fs00335-012-9407-1
Original languageEnglish
Pages (from-to)514-524
Number of pages11
JournalMammalian Genome
Volume23
Issue number9-10
DOIs
Publication statusPublished - Oct 2012

Abstract

eMouseAtlas (www.emouseatlas.org) is a comprehensive online resource to visualise mouse development and investigate gene expression in the mouse embryo. We have recently deployed a completely redesigned Mouse Anatomy Atlas website (www.emouseatlas.org/emap/ema) that allows users to view 3D embryo reconstructions, delineated anatomy, and high-resolution histological sections. A new feature of the website is the IIP3D web tool that allows a user to view arbitrary sections of 3D embryo reconstructions using a web browser. This feature provides interactive access to very high-volume 3D images via a tiled pan-and-zoom style interface and circumvents the need to download large image files for visualisation. eMouseAtlas additionally includes EMAGE (Edinburgh Mouse Atlas of Gene Expression) (www.emouseatlas.org/emage), a freely available, curated online database of in situ gene expression patterns, where gene expression domains extracted from raw data images are spatially mapped into atlas embryo models. In this way, EMAGE introduces a spatial dimension to transcriptome data and allows exploration of the spatial similarity between gene expression patterns. New features of the EMAGE interface allow complex queries to be built, and users can view and compare multiple gene expression patterns.EMAGE now includes mapping of 3D gene expression domains captured using the imaging technique optical projection tomography. 3D mapping uses WlzWarp, an open-source software tool developed by eMouseAtlas.

    Research areas

  • UPDATE, GENE-EXPRESSION, DATABASE, ATLASES, MOUSE EMBRYO

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