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Engineering large animal models of human disease: Domesticated Animal Models of Human Disease

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    Rights statement: © 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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http://doi.wiley.com/10.1002/path.4648
Original languageEnglish
Pages (from-to)247-256
JournalThe Journal of Pathology
Volume238
Issue number2
Early online date28 Sep 2015
DOIs
StatePublished - Jan 2016

Abstract

The recent development of gene editing tools and methodology for use in livestock enables the production of new animal disease models. These tools facilitate site-specific mutation of the genome allowing animals carrying known human disease mutations to be produced. In this review, we describe the various gene editing tools and how they can be used for a range of large animal models of diseases. This genomic technology is in its infancy but the expectation is that through the use of gene editing tools we will see a dramatic increase in animal model resources available for both the study of human disease and the translation of this knowledge into the clinic. Comparative pathology will be central to the productive use of these animal models and the successful translation of new therapeutic strategies.

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