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Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

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  • Bill Earnshaw
  • Robin Allshire
  • B.E. Black
  • K. Bloom
  • Edward D Salmon
  • B.R. Brinkley
  • W. Brown
  • I.M. Cheesman
  • K.H.A. Choo
  • G.P. Copenhaver
  • J.G. DeLuca
  • et al (47 other authors)

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http://link.springer.com/article/10.1007%2Fs10577-013-9347-y
Original languageEnglish
Pages (from-to)101-106
JournalChromosome Research
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2013

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

    Research areas

  • centromere , CENP-A , histone , kinetochore , CenH3

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