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European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Research output: Contribution to journalArticle

  • Lisa Vermunt
  • Colin D. Veal
  • Lea Ter Meulen
  • Charalambos Chrysostomou
  • Wiesje Van Der Flier
  • Giovanni B. Frisoni
  • Idris Guessous
  • Miia Kivipelto
  • Moira Marizzoni
  • Pablo Martinez-lage
  • José Luis Molinuevo
  • David Porteous
  • Karen Ritchie
  • Philip Scheltens
  • Pierre-jean Ousset
  • Craig W. Ritchie
  • Gerald Luscan
  • Anthony J. Brookes
  • Pieter Jelle Visser

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https://linkinghub.elsevier.com/retrieve/pii/S1552526018300645
Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalAlzheimer's & Dementia
Volume14
Issue number6
Early online date28 Mar 2018
DOIs
Publication statusPublished - 1 Jun 2018

Abstract

Introduction
It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.

Methods
A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.

Results
To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.

Discussion
This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

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