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Evaluation of equine laminar vein function: harvesting, dissection and the use of functional methods to distinguish between veins and arteries

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Original languageEnglish
Pages (from-to)92-9
Number of pages8
JournalJournal of Pharmacological and Toxicological Methods
Volume57
Issue number2
DOIs
StatePublished - 2008

Abstract

Pharmacological evaluation of the unique equine laminar microvasculature is crucial to understanding its role in health and in diseases such as laminitis. However, separating the distinctive characteristics of arterial versus venous components of this complex vascular network has previously proved to be extremely difficult. Encased in a hard hoof capsule, isolation of individual blood vessels presents a considerable challenge. Exacerbating this difficulty, the laminar venous network is adapted to sustain high intravascular pressures and consequently has thickened walls, making the normally straightforward visual distinction between arteries and veins problematic. Here we describe a novel harvesting and dissection method coupled with a functional analysis procedure that facilitates distinction of arteries and veins.

    Research areas

  • Animals, Arteries, Dissection, Endothelin-1, Foot, Hoof and Claw, Horses, Regional Blood Flow, Specimen Handling, Vasoconstriction, Veins

ID: 661004