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Experimental design for inference over the A. thaliana circadian clock network

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Original languageEnglish
Title of host publicationComputational Methods in Systems Biology
Subtitle of host publication13th International Conference, CMSB 2015, Nantes, France, September 16-18, 2015, Proceedings
PublisherSpringer International Publishing
Pages28-39
Number of pages12
ISBN (Electronic)978-3-319-23401-4
ISBN (Print)978-3-319-23400-7
DOIs
StatePublished - 2015

Publication series

NameLecture Notes in Computer Science
PublisherSpringer International Publishing
Volume9308
ISSN (Print)0302-9743

Abstract

Planning experiments is a crucial step in successful investigations, which can greatly benefit from computational modeling approaches. Here we consider the problem of designing informative experiments for elucidating the dynamics of biological networks. Our approach extends previously proposed methodologies to the important case where the structure of the network is also uncertain. We demonstrate our approach on a benchmark scenario in plant biology, the circadian clock network of Arabidopsis thaliana, and discuss the different value of three types of commonly used experiments in terms of aiding the reconstruction of the unknown network

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