Edinburgh Research Explorer

Expression pattern of Dll4 during chick embryogenesis

Research output: Contribution to journalArticle

  • Suresh Nimmagadda
  • Poongodi Geetha-Loganathan
  • Felicitas Pröls
  • Martin Scaal
  • Bodo Christ
  • Ruijin Huang

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)147-52
Number of pages6
JournalHistochemistry and cell biology
Issue number2
Publication statusPublished - Aug 2007


Notch and Delta signaling regulates cell-fate decisions in a variety of tissues in diverse organisms through cell-to-cell interactions. In this study we isolated a 696 bp fragment of chick Delta-like 4 (Dll4) cDNA and analyzed its expression pattern during chick development by in situ hybridization. We report a detailed description of cDll4 expression from HH-stage 8-30. Expression is seen in extraembryonic tissues and in the dorsal aorta throughout development but is absent from venules. Dll4 is expressed in the embryonic blood vessels, heart, somites, neural tube, limb, pharyngeal arches, esophagus, and in the developing eye. In accordance with the report from mice, cDll4 is a marker of the arterial type of endothelial cells. These analyses show that Dll4 is expressed in a wide range of tissues and organs suggesting its role in vascular development during chick embryogenesis.

    Research areas

  • Animals, Avian Proteins, Chick Embryo, Chickens, Embryonic Development, Endothelial Cells, Gene Expression Regulation, Developmental, In Situ Hybridization, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Receptors, Notch, Signal Transduction

ID: 13096400