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FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression

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  • Katharine M Hardy
  • Tatiana A Yatskievych
  • Jh Konieczka
  • Alexander S Bobbs
  • Parker B Antin

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    Rights statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Original languageEnglish
Pages (from-to)20
JournalDevelopmental Biology
Volume11
DOIs
Publication statusPublished - 2011

Abstract

FGF signalling regulates numerous aspects of early embryo development. During gastrulation in amniotes, epiblast cells undergo an epithelial to mesenchymal transition (EMT) in the primitive streak to form the mesoderm and endoderm. In mice lacking FGFR1, epiblast cells in the primitive streak fail to downregulate E-cadherin and undergo EMT, and cell migration is inhibited. This study investigated how FGF signalling regulates cell movement and gene expression in the primitive streak of chicken embryos.

    Research areas

  • Animals, Blotting, Western, Cadherins, Cell Movement, Chick Embryo, Electroporation, Fibroblast Growth Factors, Gastrulation, Gene Expression, Gene Expression Regulation, Developmental, In Situ Hybridization, Microarray Analysis, Mitogen-Activated Protein Kinases, Phosphatidylinositol 3-Kinases, Polymerase Chain Reaction, Primitive Streak, Proto-Oncogene Proteins c-akt, Receptors, Fibroblast Growth Factor, Signal Transduction, Transcription Factors, ras Proteins

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