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Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study

Research output: Contribution to journalArticle

  • Divya Mohan
  • Julia R Forman
  • Matthew Allinder
  • Carmel M McEniery
  • Charlotte Emma Bolton
  • John R Cockcroft
  • William MacNee
  • Jonathan Fuld
  • Mellone Marchong
  • Nichola Sian Gale
  • Marie Fisk
  • Sridevi Nagarajan
  • Joseph Cheriyan
  • David A Lomas
  • Peter M A Calverley
  • Bruce E Miller
  • Ruth Tal-Singer
  • Ian B Wilkinson
  • Michael I Polkey
  • ERICA Consortium

Related Edinburgh Organisations

Original languageEnglish
JournalThorax
Early online date4 Apr 2018
DOIs
Publication statusE-pub ahead of print - 4 Apr 2018

Abstract

Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator-fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction (QMVC) force and fibrinogen were measured in 729 patients with stable, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II-IV COPD. The cardiovascular and muscular manifestations exist independently (P=0.22, χ2). Fibrinogen was not associated with aPWV or QMVC (P=0.628 and P=0.621, respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.

    Research areas

  • Journal Article

ID: 64656073