Edinburgh Research Explorer

Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: Open Access Article. Published on 18 December 2019. Downloaded on 1/14/2020 2:29:53 PM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

    Final published version, 1.97 MB, PDF document

    Licence: Creative Commons: Attribution (CC-BY)

http://xlink.rsc.org/?DOI=C9SC05558D
Original languageEnglish
JournalChemical Science
Early online date18 Dec 2019
DOIs
Publication statusE-pub ahead of print - 18 Dec 2019

Abstract

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.

Download statistics

No data available

ID: 130136385