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Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

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    Rights statement: Open Access Article. Published on 18 December 2019. Downloaded on 1/14/2020 2:29:53 PM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

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Original languageEnglish
JournalChemical Science
Early online date18 Dec 2019
Publication statusE-pub ahead of print - 18 Dec 2019


Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.

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