Edinburgh Research Explorer

Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Final published version, 3 MB, PDF document

    Licence: Creative Commons: Attribution (CC-BY)

http://xlink.rsc.org/?DOI=C6TB01110A
Original languageEnglish
Pages (from-to)5405-5411
JournalJournal of Materials Chemistry B
Volume4
Issue number32
Early online date18 Jul 2016
DOIs
Publication statusE-pub ahead of print - 18 Jul 2016

Abstract

Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.

Download statistics

No data available

ID: 27408800