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GABAergic Projections from the Medial Septum Selectively Inhibit Interneurons in the Medial Entorhinal Cortex

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    Rights statement: Copyright © 2014 Gonzalez-Sulser et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Original languageEnglish
Pages (from-to)16739-16743
Number of pages5
JournalJournal of Neuroscience
Volume34
Issue number50
DOIs
Publication statusPublished - 10 Dec 2014

Abstract

The medial septum (MS) is required for theta rhythmic oscillations and grid cell firing in the medial entorhinal cortex (MEC). While GABAergic, glutamatergic, and cholinergic neurons project from the MS to the MEC, their synaptic targets are unknown. To investigate whether MSneurons innervate specific layers and cell types in the MEC, we expressed channelrhodopsin-2 in mouse MSneurons and used patch-clamp recording in brain slices to determine the response to light activation of identified cells in the MEC. Following activation of MS axons, we observed fast monosynaptic GABAergic IPSPs in the majority (>60%) of fast-spiking (FS) and low-threshold-spiking (LTS) interneurons in all layers of the MEC, but in only 1.5% of nonstellate principal cells (NSPCs) and in no stellate cells. We also observed fast glutamatergic responses to MS activation in a minority (

    Research areas

  • gamma, interneuron, lamina organization, medial entorhinal cortex, medial septum, theta, GAMMA OSCILLATIONS, THETA-RHYTHM, LAYER-II, SPATIAL PERIODICITY, FIRING FIELDS, GRID CELLS, NEURONS, RAT, HIPPOCAMPUS, AREA

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