Research output: Contribution to journal › Article › peer-review
Rights statement: Copyright © 2014 Gonzalez-Sulser et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Final published version, 1.82 MB, PDF document
Licence: Creative Commons: Attribution (CC-BY)
Original language | English |
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Pages (from-to) | 16739-16743 |
Number of pages | 5 |
Journal | Journal of Neuroscience |
Volume | 34 |
Issue number | 50 |
DOIs | |
Publication status | Published - 10 Dec 2014 |
The medial septum (MS) is required for theta rhythmic oscillations and grid cell firing in the medial entorhinal cortex (MEC). While GABAergic, glutamatergic, and cholinergic neurons project from the MS to the MEC, their synaptic targets are unknown. To investigate whether MSneurons innervate specific layers and cell types in the MEC, we expressed channelrhodopsin-2 in mouse MSneurons and used patch-clamp recording in brain slices to determine the response to light activation of identified cells in the MEC. Following activation of MS axons, we observed fast monosynaptic GABAergic IPSPs in the majority (>60%) of fast-spiking (FS) and low-threshold-spiking (LTS) interneurons in all layers of the MEC, but in only 1.5% of nonstellate principal cells (NSPCs) and in no stellate cells. We also observed fast glutamatergic responses to MS activation in a minority (
ID: 18945695