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Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits

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Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits. / Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera-Cardenas, Claudia; Karaman, Ibrahim; Liang Ng, Fu ; Evangelou, Marina ; Witkowska, Katarzyna; Tzanis, Evan ; Hellwege, Jacklyn N ; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael; Wilson, Peter W F; Tsao, Philip S; Kovesdy, Csaba P; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stephanie; Ding, Jun; Giulianini, Franco; Holliday, Elizabeth G; Jackson, Anne U.; Li-Gao, Ruifang; Lin, Wei-Yu; Luan, Jian'an; Mangino, Massimo; Oldmeadow, Christopher; Prins, Bram Peter; Qian, Yong; Sargurupremraj, Muralidharan; Shah, Nabi; Surendran, Praveen; Theriault, Sebastien; Verweij, Niek; Willems, Sara M.; Zhao, Jing Hua; Amouyel, Philippe; Connell, John M C; de Mutsert, Renee; Doney, Alex S. F.; Farrall, Martin; Menni, Cristina; Morris, Andrew; Noordam, Raymond; Paré, Guillaume; Poulter, Neil R; Shields, Denis C.; Stanton, Alice V.; Thom, Simon; Abecasis, Gonçalo R; Amin, Najaf; Arking, Dan E.; Ayers, Kristin L.; Barbieri, Caterina M; Batini, Chiara; Bis, Joshua C.; Blake, Tineka; Bochud, Murielle; Boehnke, Michael; Boerwinkle, Eric; Boomsma, Dorret I.; Bottinger, Erwin P.; Braund, Peter S; Brumat, Marco; Campbell, Archibald; Campbell, Harry; Chakravarti, Aravinda; Chambers, John C.; Chauhan, Ganesh; Ciullo, Marina; Cocca, Massimiliano; Collins, Francis S.; Cordell, Heather J.; Davies, Gail; de Borst, Martin H; Geus, Eco J. C.; Deary, Ian; Deelen, Joris; Del Greco, Fabiola M.; Demirkale, Yusuf; Dörr, Marcus; Ehret, Georg B.; Elosua, Roberto; Enroth, Stefan; Erzurumluoglu, A Mesut; Ferreira, Teresa; Frånberg, Mattias; Franco, Oscar H.; Gandin, Ilaria; Gasparini, Paolo; Giedraitis, Vilmantas; Gieger, Christian; Girotto, Giorgia; Goel, Anuj; Gow, Alan J.; Gudnason, Vilmundur; Guo, Xiuqing; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B.; Harris, Sarah; Hartman, Catharina A.; Havulinna, Aki S.; Hicks, Andrew A.; Hofer, Edith; Hofman, Albert; Hottenga, Jouke-Jan; Huffman, Jennifer E.; Hwang, Shih-Jen; Ingelsson, Erik; James, Alan L; Jansen, Rick; Jarvelin, Marjo-Riitta; Joehanes, Roby; Johansson, Åsa; Johnson, Andrew D; Joshi, Peter; Jousilahti, Pekka; Jukema, J. Wouter; Jula, Antti; Kähönen, Mika; Kathiresan, Sekar; Keavney, Bernard D.; Khaw, Kay Tee; Knekt, Paul; Knight, Joanne; Kolcic, Ivana; Kooner, Jaspal S.; Koskinen, Seppo; Kristiansson, Kati; Kutalik, Zoltan; Laan, Maris; Larson, Marty; Launer, Lenore J.; Lehne, Benjamin; Lehtimäki, Terho; Liewald, David; Lin, Li; Lind, Lars; Lindgren, Cecilia M; Liu, Yongmei; Loos, Ruth Jf; Lopez, Lorna; Lu, Yingchang; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Mamasoula, Chrysovalanto; Marrugat, Jaume; Marten, Jonathan; Milaneschi, Yuri; Morgan, Anna; Morris, Andrew P.; Morrison, Alanna C.; Munson, Peter J.; Nalls, Mike A.; Nandakumar, Priyanka; Nelson, Christopher P.; Niiranen, Teemu; Nolte, Ilja M.; Nutile, Teresa; Oldehinkel, Albertine J; Oostra, Ben A.; O'Reilly, Paul F.; Org, Elin; Padmanabhan, Sandosh; Palmas, Walter; Palotie, Aarno; Pattie, Alison; Penninx, B W J H; Perola, Markus; Peters, Annette; Polasek, Ozren; Pramstaller, Peter P.; Tri Nguyen, Quang; Raitakari, Olli T.; Ren, Meixia; Rettig, Rainer; Rice, Kenneth M.; Ridker, Paul M.; Ried, Janina S.; Riese, Harriette; Ripatti, Samuli; Robino, Antonietta; Rose, Lynda M.; Rotter, Jerome I.; Rudan, Igor; Ruggiero, Daniela; Saba, Yasaman; Sala, Cinzia F; Salomaa, Veikko; Samani, Nilesh J; Sarin, Antti-Pekka; Schmidt, Reinhold; Schmidt, Helena; Shrine, Nick R G; Siscovick, David S.; Smith, Albert Vernon; Snieder, Harold; Sõber, Siim; Sorice, Rossella; Starr, John; Stott, David J; Strachan, David P; Strawbridge, Rona J.; Sundstrom, Johan; Swertz, Morris A.; Taylor, Kent D.; Teumer, Alexander; Tobin, Martin D; Tomaszewski, Maciej; Toniolo, Daniela; Traglia, Michela; Trompet, Stella; Tuomilehto, Jaakko; Tzourio, Christophe; Uitterlinden, André G; Vaez, Ahmad; van der Most, Peter J; van Duijn, Cornelia M; Vergnaud, Anne-Claire; Verwoert, Germaine C.; Vitart, Veronique; Völker, Uwe; Vollenweider, Peter; Vuckovic, Dragana; Watkins, Hugh; Wild, Sarah; Willemsen, Gonneke; Wilson, James; Wrightl, Alan F.; Yao, Jie; Zemunik, Tatijana; Zhang, Weihua; Attia, John; Butterworth, Adam S; Chasman, Daniel I.; Conen, David; Cucca, Francesco; Danesh, John; Hayward, Caroline; Howson, Joanna MM ; Laakso, Markku; Lakatta, Edward G.; Langenberg, Claudia; Melander, Olle; Mook-Kanamori, Dennis O; Palmer, Colin N A; Risch, Lorenz; Scott, Robert A.; Scott, Rodney J; Sever, Peter; Spector, Tim D; van der Harst, Pim; Wareham, Nicholas J; Zeggini, Eleftheria; Levy, Daniel; Munroe, Patricia B; Newton-Cheh, Christopher; Brown, Morris J; Metspalu, Andres; Hung, Adriana M; O'Donnell, Christopher J.; Edwards, Todd L; Psaty, Bruce M.; Tzoulaki, Ioanna; Barnes, Michael R; Wain, Louise V; Elliott, Paul; Caulfield, Mark J.

In: Nature Genetics, Vol. 50, 17.09.2018, p. 1412–1425.

Research output: Contribution to journalArticle

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Evangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera-Cardenas, C, Karaman, I, Liang Ng, F, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Velez Edwards, DR, Sun, YV, Cho, K, Gaziano, JM, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Lin, W-Y, Luan, J, Mangino, M, Oldmeadow, C, Prins, BP, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Theriault, S, Verweij, N, Willems, SM, Zhao, JH, Amouyel, P, Connell, JMC, de Mutsert, R, Doney, ASF, Farrall, M, Menni, C, Morris, A, Noordam, R, Paré, G, Poulter, NR, Shields, DC, Stanton, AV, Thom, S, Abecasis, GR, Amin, N, Arking, DE, Ayers, KL, Barbieri, CM, Batini, C, Bis, JC, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, DI, Bottinger, EP, Braund, PS, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, JC, Chauhan, G, Ciullo, M, Cocca, M, Collins, FS, Cordell, HJ, Davies, G, de Borst, MH, Geus, EJC, Deary, I, Deelen, J, Del Greco, FM, Demirkale, Y, Dörr, M, Ehret, GB, Elosua, R, Enroth, S, Erzurumluoglu, AM, Ferreira, T, Frånberg, M, Franco, OH, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, AJ, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, TB, Harris, S, Hartman, CA, Havulinna, AS, Hicks, AA, Hofer, E, Hofman, A, Hottenga, J-J, Huffman, JE, Hwang, S-J, Ingelsson, E, James, AL, Jansen, R, Jarvelin, M-R, Joehanes, R, Johansson, Å, Johnson, AD, Joshi, P, Jousilahti, P, Jukema, JW, Jula, A, Kähönen, M, Kathiresan, S, Keavney, BD, Khaw, KT, Knekt, P, Knight, J, Kolcic, I, Kooner, JS, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, LJ, Lehne, B, Lehtimäki, T, Liewald, D, Lin, L, Lind, L, Lindgren, CM, Liu, Y, Loos, RJ, Lopez, L, Lu, Y, Lyytikäinen, L-P, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, AP, Morrison, AC, Munson, PJ, Nalls, MA, Nandakumar, P, Nelson, CP, Niiranen, T, Nolte, IM, Nutile, T, Oldehinkel, AJ, Oostra, BA, O'Reilly, PF, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Penninx, BWJH, Perola, M, Peters, A, Polasek, O, Pramstaller, PP, Tri Nguyen, Q, Raitakari, OT, Ren, M, Rettig, R, Rice, KM, Ridker, PM, Ried, JS, Riese, H, Ripatti, S, Robino, A, Rose, LM, Rotter, JI, Rudan, I, Ruggiero, D, Saba, Y, Sala, CF, Salomaa, V, Samani, NJ, Sarin, A-P, Schmidt, R, Schmidt, H, Shrine, NRG, Siscovick, DS, Smith, AV, Snieder, H, Sõber, S, Sorice, R, Starr, J, Stott, DJ, Strachan, DP, Strawbridge, RJ, Sundstrom, J, Swertz, MA, Taylor, KD, Teumer, A, Tobin, MD, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, AG, Vaez, A, van der Most, PJ, van Duijn, CM, Vergnaud, A-C, Verwoert, GC, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, S, Willemsen, G, Wilson, J, Wrightl, AF, Yao, J, Zemunik, T, Zhang, W, Attia, J, Butterworth, AS, Chasman, DI, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, JMM, Laakso, M, Lakatta, EG, Langenberg, C, Melander, O, Mook-Kanamori, DO, Palmer, CNA, Risch, L, Scott, RA, Scott, RJ, Sever, P, Spector, TD, van der Harst, P, Wareham, NJ, Zeggini, E, Levy, D, Munroe, PB, Newton-Cheh, C, Brown, MJ, Metspalu, A, Hung, AM, O'Donnell, CJ, Edwards, TL, Psaty, BM, Tzoulaki, I, Barnes, MR, Wain, LV, Elliott, P & Caulfield, MJ 2018, 'Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits', Nature Genetics, vol. 50, pp. 1412–1425. https://doi.org/10.1038/s41588-018-0205-x

APA

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., ... Caulfield, M. J. (2018). Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50, 1412–1425. https://doi.org/10.1038/s41588-018-0205-x

Vancouver

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H et al. Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. 2018 Sep 17;50:1412–1425. https://doi.org/10.1038/s41588-018-0205-x

Author

Evangelou, Evangelos ; Warren, Helen R. ; Mosen-Ansorena, David ; Mifsud, Borbala ; Pazoki, Raha ; Gao, He ; Ntritsos, Georgios ; Dimou, Niki ; Cabrera-Cardenas, Claudia ; Karaman, Ibrahim ; Liang Ng, Fu ; Evangelou, Marina ; Witkowska, Katarzyna ; Tzanis, Evan ; Hellwege, Jacklyn N ; Giri, Ayush ; Velez Edwards, Digna R ; Sun, Yan V ; Cho, Kelly ; Gaziano, J Michael ; Wilson, Peter W F ; Tsao, Philip S ; Kovesdy, Csaba P ; Esko, Tonu ; Mägi, Reedik ; Milani, Lili ; Almgren, Peter ; Boutin, Thibaud ; Debette, Stephanie ; Ding, Jun ; Giulianini, Franco ; Holliday, Elizabeth G ; Jackson, Anne U. ; Li-Gao, Ruifang ; Lin, Wei-Yu ; Luan, Jian'an ; Mangino, Massimo ; Oldmeadow, Christopher ; Prins, Bram Peter ; Qian, Yong ; Sargurupremraj, Muralidharan ; Shah, Nabi ; Surendran, Praveen ; Theriault, Sebastien ; Verweij, Niek ; Willems, Sara M. ; Zhao, Jing Hua ; Amouyel, Philippe ; Connell, John M C ; de Mutsert, Renee ; Doney, Alex S. F. ; Farrall, Martin ; Menni, Cristina ; Morris, Andrew ; Noordam, Raymond ; Paré, Guillaume ; Poulter, Neil R ; Shields, Denis C. ; Stanton, Alice V. ; Thom, Simon ; Abecasis, Gonçalo R ; Amin, Najaf ; Arking, Dan E. ; Ayers, Kristin L. ; Barbieri, Caterina M ; Batini, Chiara ; Bis, Joshua C. ; Blake, Tineka ; Bochud, Murielle ; Boehnke, Michael ; Boerwinkle, Eric ; Boomsma, Dorret I. ; Bottinger, Erwin P. ; Braund, Peter S ; Brumat, Marco ; Campbell, Archibald ; Campbell, Harry ; Chakravarti, Aravinda ; Chambers, John C. ; Chauhan, Ganesh ; Ciullo, Marina ; Cocca, Massimiliano ; Collins, Francis S. ; Cordell, Heather J. ; Davies, Gail ; de Borst, Martin H ; Geus, Eco J. C. ; Deary, Ian ; Deelen, Joris ; Del Greco, Fabiola M. ; Demirkale, Yusuf ; Dörr, Marcus ; Ehret, Georg B. ; Elosua, Roberto ; Enroth, Stefan ; Erzurumluoglu, A Mesut ; Ferreira, Teresa ; Frånberg, Mattias ; Franco, Oscar H. ; Gandin, Ilaria ; Gasparini, Paolo ; Giedraitis, Vilmantas ; Gieger, Christian ; Girotto, Giorgia ; Goel, Anuj ; Gow, Alan J. ; Gudnason, Vilmundur ; Guo, Xiuqing ; Gyllensten, Ulf ; Hamsten, Anders ; Harris, Tamara B. ; Harris, Sarah ; Hartman, Catharina A. ; Havulinna, Aki S. ; Hicks, Andrew A. ; Hofer, Edith ; Hofman, Albert ; Hottenga, Jouke-Jan ; Huffman, Jennifer E. ; Hwang, Shih-Jen ; Ingelsson, Erik ; James, Alan L ; Jansen, Rick ; Jarvelin, Marjo-Riitta ; Joehanes, Roby ; Johansson, Åsa ; Johnson, Andrew D ; Joshi, Peter ; Jousilahti, Pekka ; Jukema, J. Wouter ; Jula, Antti ; Kähönen, Mika ; Kathiresan, Sekar ; Keavney, Bernard D. ; Khaw, Kay Tee ; Knekt, Paul ; Knight, Joanne ; Kolcic, Ivana ; Kooner, Jaspal S. ; Koskinen, Seppo ; Kristiansson, Kati ; Kutalik, Zoltan ; Laan, Maris ; Larson, Marty ; Launer, Lenore J. ; Lehne, Benjamin ; Lehtimäki, Terho ; Liewald, David ; Lin, Li ; Lind, Lars ; Lindgren, Cecilia M ; Liu, Yongmei ; Loos, Ruth Jf ; Lopez, Lorna ; Lu, Yingchang ; Lyytikäinen, Leo-Pekka ; Mahajan, Anubha ; Mamasoula, Chrysovalanto ; Marrugat, Jaume ; Marten, Jonathan ; Milaneschi, Yuri ; Morgan, Anna ; Morris, Andrew P. ; Morrison, Alanna C. ; Munson, Peter J. ; Nalls, Mike A. ; Nandakumar, Priyanka ; Nelson, Christopher P. ; Niiranen, Teemu ; Nolte, Ilja M. ; Nutile, Teresa ; Oldehinkel, Albertine J ; Oostra, Ben A. ; O'Reilly, Paul F. ; Org, Elin ; Padmanabhan, Sandosh ; Palmas, Walter ; Palotie, Aarno ; Pattie, Alison ; Penninx, B W J H ; Perola, Markus ; Peters, Annette ; Polasek, Ozren ; Pramstaller, Peter P. ; Tri Nguyen, Quang ; Raitakari, Olli T. ; Ren, Meixia ; Rettig, Rainer ; Rice, Kenneth M. ; Ridker, Paul M. ; Ried, Janina S. ; Riese, Harriette ; Ripatti, Samuli ; Robino, Antonietta ; Rose, Lynda M. ; Rotter, Jerome I. ; Rudan, Igor ; Ruggiero, Daniela ; Saba, Yasaman ; Sala, Cinzia F ; Salomaa, Veikko ; Samani, Nilesh J ; Sarin, Antti-Pekka ; Schmidt, Reinhold ; Schmidt, Helena ; Shrine, Nick R G ; Siscovick, David S. ; Smith, Albert Vernon ; Snieder, Harold ; Sõber, Siim ; Sorice, Rossella ; Starr, John ; Stott, David J ; Strachan, David P ; Strawbridge, Rona J. ; Sundstrom, Johan ; Swertz, Morris A. ; Taylor, Kent D. ; Teumer, Alexander ; Tobin, Martin D ; Tomaszewski, Maciej ; Toniolo, Daniela ; Traglia, Michela ; Trompet, Stella ; Tuomilehto, Jaakko ; Tzourio, Christophe ; Uitterlinden, André G ; Vaez, Ahmad ; van der Most, Peter J ; van Duijn, Cornelia M ; Vergnaud, Anne-Claire ; Verwoert, Germaine C. ; Vitart, Veronique ; Völker, Uwe ; Vollenweider, Peter ; Vuckovic, Dragana ; Watkins, Hugh ; Wild, Sarah ; Willemsen, Gonneke ; Wilson, James ; Wrightl, Alan F. ; Yao, Jie ; Zemunik, Tatijana ; Zhang, Weihua ; Attia, John ; Butterworth, Adam S ; Chasman, Daniel I. ; Conen, David ; Cucca, Francesco ; Danesh, John ; Hayward, Caroline ; Howson, Joanna MM ; Laakso, Markku ; Lakatta, Edward G. ; Langenberg, Claudia ; Melander, Olle ; Mook-Kanamori, Dennis O ; Palmer, Colin N A ; Risch, Lorenz ; Scott, Robert A. ; Scott, Rodney J ; Sever, Peter ; Spector, Tim D ; van der Harst, Pim ; Wareham, Nicholas J ; Zeggini, Eleftheria ; Levy, Daniel ; Munroe, Patricia B ; Newton-Cheh, Christopher ; Brown, Morris J ; Metspalu, Andres ; Hung, Adriana M ; O'Donnell, Christopher J. ; Edwards, Todd L ; Psaty, Bruce M. ; Tzoulaki, Ioanna ; Barnes, Michael R ; Wain, Louise V ; Elliott, Paul ; Caulfield, Mark J. / Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits. In: Nature Genetics. 2018 ; Vol. 50. pp. 1412–1425.