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Genome-wide association identify regions underlying bovine tuberculosis resistance in dairy cattle

Research output: Contribution to conferenceAbstractpeer-review

Original languageEnglish
Pages188
Number of pages1
Publication statusPublished - 29 Aug 2016
EventEAAP 2016 67th Annual Meeting of the European Federation of Animal Science - Ireland, Belfast, United Kingdom
Duration: 29 Aug 20162 Sep 2016

Conference

ConferenceEAAP 2016 67th Annual Meeting of the European Federation of Animal Science
CountryUnited Kingdom
CityBelfast
Period29/08/162/09/16

Abstract

The significant social disruption and economic losses from bovine tuberculosis (bTB) due to infection from Mycobacterium bovis present an ongoing challenge to the cattle industries in the UK and worldwide. Genetic variation in cattle provides an opportunity to select for more resistant animals. The objective of this study was to identify genomic regions associated with resistance to bTB in dairy cattle using Genome-Wide Association Study (GWAS) and Regional Heritability Mapping (RHM). In the latter, regions consisting of 100 SNPs and overlapping by 50 SNPs were defined and analysed. De-regressed estimated breeding values (dEBV) for susceptibility to bTB were calculated for Holstein Friesian bulls based on bTB skin test records of their daughters and then used as phenotypes. A total of 529 bulls with dEBV and 50K SNP genotypes were considered. Of the 56,134 SNPs, 36,625 SNPs were retained for analyses following quality control. GWAS identified two SNPs on chromosomes 4 and 17 which were suggestive (i.e. one false positive per genome scan) of association with bTB resistance at -log10(P-value) of 4.56. The estimated SNP-based polygenic heritability for resistance to bTB was 0.45±0.11. RHM identified genomic regions on chromosomes 10 and 17, all of which were significant at a suggestive level of –log10(P-value) of 2.57. The proportion of total phenotypic variance accounted for by these regions was 0.05 and 0.10-0.11 for chromosomes 10 and 17, respectively. The
genomic regions identified in this study provide an opportunity for exploration of plausible candidate genes and contribute to the understanding of the pathways involved in cattle resistance to bTB.

Event

EAAP 2016 67th Annual Meeting of the European Federation of Animal Science

29/08/162/09/16

Belfast, United Kingdom

Event: Conference

ID: 27702472