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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

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Original languageEnglish
Pages (from-to)e1006528
Number of pages26
JournalPLoS Genetics
Volume13
Issue number4
DOIs
Publication statusPublished - 27 Apr 2017

Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To 381 identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction 382 meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 383 adults of European (n=180,423) or other ancestry (n=20,029). We standardized PA by categorizing it 384 into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 385 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-386 risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals 387 compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In 388 additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel 389 adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to 390 variation in adiposity may facilitate gene discovery

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