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Genome-wide transcriptomic analysis of intestinal tissue to assess the impact of nutrition and a secondary nematode challenge in lactating rats

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  • Spiridoula Athanasiadou
  • Leigh A Jones
  • Stewart T G Burgess
  • Ilias Kyriazakis
  • Alan D Pemberton
  • Jos G M Houdijk
  • John F Huntley

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Original languageEnglish
Article numbere20771
JournalPLoS ONE
Volume6
Issue number6
DOIs
Publication statusPublished - 2011

Abstract

Gastrointestinal nematode infection is a major challenge to the health and welfare of mammals. Although mammals eventually acquire immunity to nematodes, this breaks down around parturition, which renders periparturient mammals susceptible to re-infection and an infection source for their offspring. Nutrient supplementation reduces the extent of periparturient parasitism, but the underlying mechanisms remain unclear. Here, we use a genome wide approach to assess the effects of protein supplementation on gene expression in the small intestine of periparturient rats following nematode re-infection.

    Research areas

  • Animals, Gene Expression Profiling, Genome, Intestines, Lactation, Nippostrongylus, Nutritional Status, Oligonucleotide Array Sequence Analysis, Rats, Strongylida Infections

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