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Global gene expression analysis of chicken caecal response to Campylobacter jejuni

Research output: Contribution to journalArticle

  • Ronan G Shaughnessy
  • Kieran G Meade
  • Beatrice A McGivney
  • Brenda Allan
  • Cliona O'Farrelly

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume142
Issue number1-2
DOIs
Publication statusPublished - 15 Jul 2011

Abstract

Campylobacter jejuni colonises the caecum of more than 90% of commercial chickens. Even though colonisation is asymptomatic, we hypothesised that it is mediated by activation of several biological pathways. We therefore used chicken-specific 20K oligonucleotide microarrays to examine global gene expression in C. jejuni-challenged birds. Microarray results demonstrate small but significant fold-changes in expression of 270 genes 20 h post-challenge, corresponding to a wide range of biological processes including cell growth, nutrient metabolism and immunological activity. Expression of NOX1 (2.3-fold) and VCAM1 (1.5-fold) were significantly increased in colonised birds (P

    Research areas

  • Animals, Campylobacter Infections, Campylobacter jejuni, Cecum, Chickens, Gene Expression Profiling, Gene Expression Regulation, Genes, Immunity, Oligonucleotide Array Sequence Analysis, Poultry Diseases

ID: 13081084