Edinburgh Research Explorer

Gold-Triggered Uncaging Chemistry in Living Systems

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

    Final published version, 2 MB, PDF-document

    Licence: Creative Commons: Attribution (CC-BY)

Original languageEnglish
JournalAngewandte Chemie
Early online date12 Jul 2017
DOIs
Publication statusE-pub ahead of print - 12 Jul 2017

Abstract

Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis andfacilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled —for the first time— the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

Download statistics

No data available

ID: 39293726