Edinburgh Research Explorer

Good Laboratory Practice Preventing Introduction of Bias at the Bench

Research output: Contribution to journalArticle

  • Malcolm R. Macleod
  • Marc Fisher
  • Victoria O'Collins
  • Emily S. Sena
  • Ulrich Dirnagl
  • Philip M. W. Bath
  • Alistair Buchan
  • H. Bart van der Worp
  • Richard Traystman
  • Kazuo Minematsu
  • Geoffrey A. Donnan
  • David W. Howells

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)E50-E52
Number of pages3
JournalStroke
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 2009

Abstract

Background and Purpose - As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.

Summary of Review - Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.

Conclusions - Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. (Stroke. 2009; 40: e50-e52.)

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