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Haemoglobin-based blood substitutes and sepsis

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Original languageEnglish
Pages (from-to)158-60
Number of pages3
JournalThe Lancet
Issue number8943
Publication statusPublished - 21 Jan 1995


An important concern that has received little attention is the possible increased susceptibility to bacterial infections of patients infused with cell-free haemoglobin-based blood substitutes. We show that pyridoxalated polymerised human haemoglobin promotes fulminating Escherichia coli septicaemia in mice, which draws attention to the potential danger of such products in the clinic.

    Research areas

  • Animals, Blood Substitutes/pharmacology, Disease Susceptibility, Escherichia coli/pathogenicity, Escherichia coli Infections/microbiology, Hemoglobins/pharmacology, Mice, Pyridoxal Phosphate/analogs & derivatives, Sepsis/microbiology

ID: 80509240