Edinburgh Research Explorer

Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function

Research output: Contribution to journalArticle

  • Richard A Oram
  • Augustin M Brooks
  • Shareen Forbes
  • Stephanie Eckoldt
  • Richard M Smith
  • Pratik Choudhary
  • Miranda J Rosenthal
  • Paul Johnson
  • Martin K Rutter
  • Keith A Burling
  • Timothy J McDonald
  • James A M Shaw
  • Andrew T Hattersley

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1737-40
Number of pages4
JournalDiabetes Care
Volume37
Issue number6
Early online date12 Mar 2014
DOIs
Publication statusPublished - Jun 2014

Abstract

OBJECTIVE: Islet graft function is defined by serum C-peptide in a standardized challenge test. We assessed whether urine C-peptide creatinine ratio (UCPCR) sent from home could provide a viable alternative.

RESEARCH DESIGN AND METHODS: Seventeen islet recipients provided 90-min serum C-peptide (sCP90) and 120-min UCPCR (UCPCR120) samples during 68 interval posttransplant mixed-meal tolerance tests, also posting from home a 120-min postbreakfast UCPCR sample every 2 weeks. UCPCR was compared with a clinical score of islet function, derived from HbA1c and insulin dose.

RESULTS: UCPCR120 and mean home postmeal UCPCR were strongly correlated with sCP90 (r(s) = 0.73, P < 0.001; and rs = 0.73, P < 0.01, respectively). Mean home UCPCR increased with clinical score (r(s) = 0.75; P < 0.001) and with graft function defined both by sCP90 >200 pmol/L and insulin independence. UCPCR cutoffs to detect insulin independence and poor graft function were sensitive and specific.

CONCLUSIONS: Home UCPCR provides a valid measure of C-peptide production in islet transplant recipients.

    Research areas

  • Aged, Biological Markers, C-Peptide, Creatinine, Diabetes Mellitus, Type 1, Female, Follow-Up Studies, Graft Survival, Humans, Insulin-Secreting Cells, Islets of Langerhans Transplantation, Male, Middle Aged, Monitoring, Physiologic, Prognosis, Prospective Studies

ID: 19314643