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Hybrid peeling for fast and accurate calling, phasing, and imputation with sequence data of any coverage in pedigrees

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Original languageEnglish
Article number67
Number of pages15
JournalGenetics Selection Evolution
Volume50
Issue number1
DOIs
Publication statusPublished - 18 Dec 2018

Abstract

In this paper, we extend multi-locus iterative peeling to provide a computationally efficient method for calling, phasing, and imputing sequence data of any coverage in small or large pedigrees. Our method, called hybrid peeling, uses multi-locus iterative peeling to estimate shared chromosome segments between parents and their offspring at a subset of loci, and then uses single-locus iterative peeling to aggregate genomic information across multiple generations at the remaining loci.

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