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Hybridization of electrodeposited magnetic multilayer micropillars

Research output: Contribution to journalArticle

  • Justin J. Palfreyman
  • Frieda van Belle
  • Wen-Siang Lew
  • Thanos Mitrelias
  • J. A. C. Bland
  • Maria Lopalco
  • Mark Bradley

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)2439-2441
Number of pages3
JournalIEEE Transactions on Magnetics
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 2007

Abstract

A novel magnetic encoding technique for performing high-throughput biological assays using molecular probes such as antibodies and DNA oligonucleotides is presented. Electrodeposited Ni/Au multilayer pillar structures with diameters from 5-20 mu m and thicknesses from 1-10 mu m are presented as "magnetic barcodes," where the number of unique codes possible increases exponentially with a linear increase in pillar size. We have successfully functionalized these pillars using a HS-C-10-NHS self-assembled monolayer (SAM) grown on the An cap layer and attachment of an NH2 modified primer oligo sequence and have shown hybridization and denaturation to a fluorescent template. In addition we have developed a novel release layer methodology that allows a large library of probes to be inkjet printed on a single 5 mm(2) chip prior to release.

    Research areas

  • DNA, electrodeposition, fluorescence, hybridization, magnetic barcodes, microarrays, microfluidics, MICROARRAY TECHNOLOGY

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