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Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat

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    Rights statement: © 2020 The Authors. Molecular Reproduction and Development published by Wiley Periodicals LLC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Original languageEnglish
JournalMolecular Reproduction and Development
Early online date27 Aug 2020
Publication statusE-pub ahead of print - 27 Aug 2020


The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females ...

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