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Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function

Research output: Contribution to journalLiterature reviewpeer-review

Original languageEnglish
Article number219
Number of pages7
JournalArthritis research & therapy
Volume11
Issue number2
DOIs
Publication statusPublished - 2009

Abstract

With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.

    Research areas

  • KAPPA-B ACTIVITY, TRANSCRIPTION FACTORS, PROLYL-HYDROXYLASES, GENE-EXPRESSION, NEUTROPHIL APOPTOSIS, HUMAN MACROPHAGES, IRON-METABOLISM, FACTOR-ALPHA, HIF-ALPHA, HIF-1-ALPHA

ID: 17165709