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Imaging inflammation: Molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution

Research output: Contribution to journalLiterature review

Original languageEnglish
Pages (from-to)182-199
Number of pages18
JournalPharmacology and Therapeutics
Volume135
Issue number2
DOIs
Publication statusPublished - Aug 2012

Abstract

Dysregulation of inflammation is central to the pathogenesis of innumerable human diseases. Understanding and tracking the critical events in inflammation are crucial for disease monitoring and pharmacological drug discovery and development. Recent progress in molecular imaging has provided novel insights into spatial associations, molecular events and temporal sequelae in the inflammatory process. While remaining a burgeoning field in pre-clinical research, increasing application in man affords researchers the opportunity to study disease pathogenesis in humans in situ thereby revolutionizing conventional understanding of pathophysiology and potential therapeutic targets. This review provides a description of commonly used molecular imaging modalities, including optical, radionuclide and magnetic resonance imaging, and details key advances and translational opportunities in imaging inflammation from initiation to resolution. (C) 2012 Elsevier Inc. All rights reserved.

    Research areas

  • Bacteria, REPORTER ENZYME FLUORESCENCE, Apoptosis, IRON-OXIDE PARTICLES, POSITRON-EMISSION-TOMOGRAPHY, Inflammation, ACUTE LUNG INJURY, KAPPA-B ACTIVATION, RESPIRATORY-DISTRESS-SYNDROME, Neutrophil, RECENT MYOCARDIAL-ISCHEMIA, MAGNETIC-RESONANCE, Molecular imaging, Imaging probes, IN-VIVO DETECTION, CELL-ADHESION MOLECULE-1

ID: 7894381