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Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome

Research output: Contribution to journalArticlepeer-review

  • A Gambineri
  • G Forlani
  • A Munarini
  • F Tomassoni
  • G E Cognigni
  • W Ciampaglia
  • U Pagotto
  • B R Walker
  • R Pasquali

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)210-8
Number of pages9
JournalJournal of Endocrinological Investigation
Issue number3
Publication statusPublished - 2009


Increased peripheral metabolism of cortisol may explain compensatory ACTH-dependent adrenal steroidogenesis and hence hyperandrogenism in polycystic ovary syndrome (PCOS). Previous studies have described an increased 5alpha-reduction of cortisol or impaired regeneration of cortisol by 11beta-HSD1 in PCOS. However, these observations may be confounded by obesity. Moreover, the relationship between alterations in cortisol metabolism and the extent of adrenal androgen hyper-secretion in response to ACTH has not been established. This study aimed to examine the association between cortisol metabolism and ACTH-dependent adrenal hyperandrogenism in PCOS, independently of obesity.

ID: 2189078