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Inducible nitric oxide synthase activity contributes to the regulation of peripheral vascular tone in patients with cirrhosis and ascites

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    Rights statement: Copyright © 2006 BMJ Publishing Group & British Society of Gastroenterology

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http://gut.bmj.com/content/55/4/542.long
Original languageEnglish
Pages (from-to)542-6
Number of pages5
JournalGut
Volume55
Issue number4
DOIs
Publication statusPublished - 2006

Abstract

Overexpression of inducible nitric oxide synthase (iNOS) and increased nitric oxide generation may be associated with the hyperdynamic circulation of patients with cirrhosis. We have, for the first time, used the highly selective iNOS inhibitor, 1400W, to determine whether iNOS activity contributes to the regulation of vascular tone in patients with cirrhosis and ascites.

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