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Infectious Bronchitis Virus induces acute interferon-gamma production through polyclonal stimulation of chicken leukocytes

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http://www.sciencedirect.com/science/article/pii/S0042682208007381
Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalVirology
Volume385
Issue number1
DOIs
Publication statusPublished - 1 Mar 2009

Abstract

Infectious Bronchitis Virus, a member of the Coronaviridae, is a respiratory pathogen in poultry. We found that in vitro stimulation with IBV resulted in ChIFN-gamma production in splenocytes of both infected birds and uninfected birds. The non-specific stimulation did not occur when other avian viruses or other coronaviruses were used or when mammalian cells were stimulated with IBV. Inactivation of IBV reduced ChIFN-gamma production, but ChIFN-gamma remained elevated compared to unstimulated cells. An increase in ChIFN-gamma mRNA was detected in splenocytes from IBV-infected and uninfected chickens as early as 1 h after stimulation with IBV. These results indicate that IBV acts as a polyclonal stimulus, inducing a rapid production of IFN-gamma even without previous exposure to the virus. (c) 2008 Elsevier Inc. All rights reserved.

    Research areas

  • SARS-COV, Interferon-gamma, PROTEIN, INDUCTION, Chicken, IFN-GAMMA, Infectious Bronchitis Virus, VACCINE DEVELOPMENT, Polyclonal stimulation, CYTOKINE RESPONSES, Superantigen, DISEASE, CORONAVIRUS, ELISPOT, ACUTE RESPIRATORY SYNDROME, REPLICATION

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