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Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese men

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Original languageEnglish
Pages (from-to)185-94
Number of pages10
JournalEuropean Journal of Endocrinology
Volume150
Issue number2
Publication statusPublished - 2004

Abstract

Obesity is associated with increased inactivation of cortisol by hepatic A-ring 5alpha- and 5beta-reductases, impaired hepatic regeneration of cortisol from cortisone by 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1), but increased subcutaneous adipose 11HSD1 activity enhancing local cortisol levels in fat. Cause and effect between obesity and abnormal cortisol metabolism is untested.

ID: 3116649