Edinburgh Research Explorer

Insulin resistance in type 1 diabetes: what is 'double diabetes' and what are the risks?

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1462-1470
Number of pages9
JournalDiabetologia
Volume56
Issue number7
DOIs
Publication statusPublished - 2013

Abstract

In this review, we explore the concept of 'double diabetes', a combination of type 1 diabetes with features of insulin resistance and type 2 diabetes. After considering whether double diabetes is a useful concept, we discuss potential mechanisms of increased insulin resistance in type 1 diabetes before examining the extent to which double diabetes might increase the risk of cardiovascular disease (CVD). We then go on to consider the proposal that weight gain from intensive insulin regimens may be associated with increased CV risk factors in some patients with type 1 diabetes, and explore the complex relationships between weight gain, insulin resistance, glycaemic control and CV outcome. Important comparisons and contrasts between type 1 diabetes and type 2 diabetes are highlighted in terms of hepatic fat, fat partitioning and lipid profile, and how these may differ between type 1 diabetic patients with and without double diabetes. In so doing, we hope this work will stimulate much-needed research in this area and an improvement in clinical practice.

    Research areas

  • Obesity Double diabetes WEIGHT-GAIN INTRAPERITONEAL INSULIN HDL-cholesterol Type 2 diabetes PITTSBURGH EPIDEMIOLOGY Review CARDIOVASCULAR-DISEASE LIPOPROTEIN COMPOSITION Insulin resistance Cardiovascular disease METABOLIC SYNDROME Type 1 diabetes Hepatic fat SERUM-LIPIDS CORONARY-ARTERY-DISEASE COMPLICATIONS TRIAL HEPATIC LIPASE ACTIVITY

ID: 25092550